Friday, October 28, 2016

High Intensity Interval Training but not Continuous Training Reverses Right Ventricular Hypertrophy and Dysfunction in a Rat Model of Pulmonary Hypertension.

High Intensity Interval Training but not Continuous Training Reverses Right Ventricular Hypertrophy and Dysfunction in a Rat Model of Pulmonary Hypertension.

Am J Physiol Regul Integr Comp Physiol. 2016 Oct 26;:ajpregu.00358.2016

Authors: Brown MB, Neves E, Long GM, Graber JB, Gladish BA, Wiseman A, Owens M, Fisher AJ, Presson RG, Petrache I, Kline JA, Lahm T


BACKGROUND: Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive RV hypertrophy associated with the disease. For chronic LV failure, high intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs. CExT in a rat model of monocrotaline- (MCT) induced mild PAH.
METHODS: Six weeks of treadmill training (5x/week) was performed, as either 30 min HIIT or 60 min low-intensity CExT. To characterize acute hemodynamic responses to the two approaches, novel recordings of simultaneous pulmonary and systemic pressures during running were obtained at pre- and 2, 4, 6, and 8 weeks post-MCT utilizing long-term implantable telemetry.
RESULTS: MCT-induced decrement in VO2max was ameliorated by both HIIT and CExT, with less pronounced pulmonary vascular remodeling and no increase in RV inflammation or apoptosis observed. Most importantly, only HIIT lowered RV systolic pressure, RV hypertrophy, and total pulmonary resistance, and prompted higher cardiac index; complemented by a RV increase in the positive inotrope apelin and reduced fibrosis. HIIT prompted a markedly pulsatile pulmonary pressure during running and was associated with greater lung endothelial nitric oxide synthase after 6 weeks.
CONCLUSION: HIIT may be superior to CExT for improving hemodynamics and maladaptive RV hypertrophy in PAH. HIIT's superior outcomes may be explained by more favorable pulmonary vascular endothelial adaptation to the pulsatile HIIT stimulus.

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