Friday, January 31, 2014

Effect of Exercise on Burn-Induced Changes in Tissue-Specific Glucose Metabolism.

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Effect of Exercise on Burn-Induced Changes in Tissue-Specific Glucose Metabolism.

J Burn Care Res. 2014 Jan 28;

Authors: Carter EA, Paul C, Bonab AA, Tompkins RG, Fischman AJ

Abstract
Exercise is a component of the clinical management for the burn patients to help reduce muscle wasting associated with prolonged hospitalization. In the present study the authors examined 2-deoxy-2-[18F] fluoro-D-glucose (FDG) uptake in mice subjected to burn injury with and without exercise. Mice had their the dorsums shaven, were placed in molds, and the exposed area was immersed in 90°C water for 9 seconds followed by resuscitation with saline (2 ml) to produce a 30% full-thickness burn injury. Twenty-four hours later, the mice were subjected to treadmill exercise for 1 hour. Before exercise, mice were injected with ~50 μCi FDG. Mice were killed after running and a complete biodistribution was performed. Exercise produced a stimulation of FDG update by skeletal muscle and heart, while reducing FDG accumulation in brain. Burn injury had no significant effect on FDG update by skeletal muscle, but did increase FDG accumulation in heart, while reducing FDG accumulation in brain. However, exercise combined with a burn injury produced a significant increase in FDG uptake in the skeletal muscle compared with the burned mice, as great as that produced in the sham animals subjected to exercise. The combination of burn plus exercise appeared to prevent the stimulation of FDG uptake by the heart produced by burn injury alone. Exercise treatment did not correct the changes in FDG uptake in the brain produced by burn injury. Separately, exercise and burn injury significantly increased serum interleukin-6 levels, increases that were higher when exercise was combined with the burn injury. These findings suggest that exercise may exert some therapeutic effects in burn patients by tissue-specific modulation of glucose metabolism, and these changes may be related to interleukin-6.

PMID: 24476988 [PubMed - as supplied by publisher]



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